The Santa Fe Hotel Tamuning sits directly on the beach of Tamunuing Bay. It is two miles from the Guam Premier Outlets and six miles from Pleasure Island. The Santa Fe Hotel Tamuning is 6 km from the international airport. The local trolley service provides linking service to the local attractions, and airport transfers can be arranged with the front desk.

There are 110 rooms at the Santa Fe Hotel Tamuning. Rooms have air conditioning and overlook either the garden, the mountains, or the ocean. Other amenities include televisions, Internet access, mini fridges, coffee makers, safe boxes, and en suite bathrooms. Non-smoking rooms are available by request.

The Santa Fe Hotel Tamuning has American Southwestern style architecture and is a bright coral pink color. It has an on site restaurant that serves meals throughout the day, and a daytime beach-side bar. Conference space is available for meetings, and wireless Internet access is available in the lobby. For relaxation, the hotel has an infinity swimming pool that overlooks Agana Bay and a Jacuzzi. Free parking is offered to guests.